La supplémentation en vitamine d prévient-elle des infections ?
Selon une revue systématique d’études randomisées publiée en 2017, il semble bien que c'est effectivement le cas. Les auteurs on constaté que la vitamine D prévient les infections du système respiratoire.
"Conclusions Vitamin D supplementation was safe and it protected against acute respiratory tract infection overall. Patients who were very vitamin D deficient and those not receiving bolus doses experienced the most benefit."
« Our study reports a major new indication for vitamin D supplementation: the prevention of acute respiratory tract infection. We also show that people who are very deficient in vitamin D and those receiving daily or weekly supplementation without additional bolus doses experienced particular benefit. Our results add to the body of evidence supporting the introduction of public health measures such as food fortification to improve vitamin D status, particularly in settings where profound vitamin D deciciency is common.”
"Subgroup analysis revealed a strong protective effect of vitamin D supplementation among those
with baseline circulating 25-hydroxyvitamin D levels less than 25 nmol/L (adjusted odds ratio 0.58, 0.40 to 0.82, NNT=8, 5 to 21; 538 participants in 14 studies; within subgroup P=0.002; see Cates plot, supplementary figure S1) and no statistically significant effect among those with baseline levels of 25 or more nmol/L (adjusted odds ratio 0.89, 0.77 to 1.04; 3634 participants in 19 studies; within subgroup P=0.15; P for interaction 0.01). This evidence was assessed as being of high quality (see supplementary table S3). An exploratory analysis testing the effects of vitamin D supplementation in those with baseline 25-hydroxyvitamin D concentrations in the ranges
25-49.9 nmol/L, 50-74.9 nmol/L, and 75 or more nmol/L did not reveal evidence of a statistically significant interaction (see supplementary table S4)".
In this individual participant data (IPD) meta-analysis of randomised controlled trials, vitamin D supplementation reduced the risk of experiencing at least one acute respiratory tract infection. Subgroup analysis revealed that daily or weekly vitamin D supplementation without additional bolus doses protected against acute respiratory tract infection, whereas regimens containing large bolus doses did not. Among those receiving daily or weekly vitamin D, protective effects were strongest in those with profound vitamin D deficiency at baseline, although those with higher baseline 25-hydroxyvitamin D concentrations also experienced benefit. This evidence was assessed as being of high quality, using the GRADE criteria."
"Use of vitamin D was safe: potential adverse reactions were rare, and the risk
of such events was the same between participants randomized to intervention and control arms."
référence : Adrian R. Martineau et al. 2017. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. British Medical Journal. http://www.bmj.com/content/356/bmj.i6583
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